Phosphatidylinositol 3-Kinase and Its Novel Product, Phosphatidylinositol 3-phosphate, Are Present in Saccharomyces cerevisiae
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چکیده
منابع مشابه
Recognizing Phosphatidylinositol 3-Phosphate
Phosphatidylinositol 3-phosphate directs the endosomal localization of regulatory proteins by binding to FYVE and PX domains. New structures of these domains complexed with the phosphoinositide headgroup show how interactions with phosphate and hydroxyl groups differentiate this lipid from all others.
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Professional phagocytic cells ingest microbial intruders by engulfing them into phagosomes, which subsequently mature into microbicidal phagolysosomes. Phagosome maturation requires sequential fusion of the phagosome with early endosomes, late endosomes, and lysosomes. Although various phosphoinositides (PIPs) have been detected on phagosomes, it remained unclear which PIPs actually govern phag...
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*Molecular Dynamics of Synaptic Function Laboratory, Queensland Brain Institute and School of Biomedical Sciences, The University of Queensland, St. Lucia, 4072 Queensland, Australia; † Centre for Microscopy and Microanalysis and Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia; and ‡Renal Section, Faculty of Medicine, Imperial College, London W...
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A number of years ago, when the raison d’#{234}tre for tyrosine kinase activity was completely unclear, one of the tantalizing leads was the apparent coincidence of inositol lipid kinase activity with certain tyrosine kinases (see, for example Refs. 1 and 2); the exciting prospect implied was a link to a well defined signal transduction pathway (for a review of inositol lipid kinases, see Ref. ...
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The Saccharomyces cerevisiae protein Fablp is the archetypal type III phosphatidyl inositol phosphate kinase. This family of enzymes is universal to all eukaryotes and is responsible for the synthesis of phosphatidylinositol 3,5-bisphosphate from phosphatidylinositol 3phosphate. In S. cerevisiae, Fablp regulates a number of cellular processes via the production of phosphatidylinositol 3,5-bisph...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1989
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)47043-9